Basic Information
VIS ID
TVIS44003915
Fusion event
HTLV-1-SLIT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
168686051/169259047 (Hg38)
End
168686051/169259047 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
SLIT3
miRNAs that regulate target gene
hsa-mir-218-2-3p ; hsa-mir-218-5p ; hsa-mir-1343-3p ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-214-3p ; hsa-mir-24-3p ; hsa-mir-3074-5p ; hsa-mir-3619-5p ; hsa-mir-3690 ; hsa-mir-4254 ; hsa-mir-4291 ; hsa-mir-4511 ; hsa-mir-6077 ; hsa-mir-646 ; hsa-mir-6783-3p ; hsa-mir-7152-5p ; hsa-mir-7-5p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10397/Upstream/490792; hsa-mir-10523/Downstream/4554;
Nearest TSS
ENST00000502646/Upstream/228609; ENST00000503209/Downstream/41699;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/679134, chr5-CpG: 94/Downstream/41378
Upstream sequence
ctccttagctatgtggctttgagaaaggcacttaacttTATGGAACTCCCATTGTTGTTGCTGTGACTTTTGTAAAACATGACCCAAAATACCACGTCTG
Downstream sequence
TCAGATCACCATGAGGCTCAATTGAGAAAGTACtttttttttggagacagagtcttgctctcttgctcaggctgaagggcagtggctcaatctcacctca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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