Basic Information
VIS ID
TVIS44003918
Fusion event
HTLV-1-HECW1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
43470782/43431183 (Hg38)
End
43470782/43431183 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
HECW1
miRNAs that regulate target gene
hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-5692a ; hsa-mir-4422 ; hsa-mir-548c-3p ; hsa-mir-6835-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p
Nearest miRNA
hsa-mir-1183/Upstream/280189; hsa-mir-10399/Downstream/620583;
Nearest TSS
ENST00000635602/Upstream/34510; ENST00000461842/Downstream/48425;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/181834, chr7-CpG: 65/Downstream/13608
Upstream sequence
atttttctttaacaATGTCTTTAACATTTCTCCAGATGATCAAGGTCTACATGAATGACTCATAGTTTCCTTGACCACTCCAATCTCTTTGACCTTCAAT
Downstream sequence
TACATTCACCATGAGCCATCTATTCCTGCACTTATACCGTAGAACTTGTTGAAATATCACAAGCTCTCCAGCCCTGTACAGTCTTCTATCCTTCCATGCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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