Basic Information
VIS ID
TVIS44003922
Fusion event
HTLV-1-ZC3H12B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
64255523/65035643 (Hg38)
End
64255523/65035643 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZC3H12B
miRNAs that regulate target gene
hsa-mir-6759-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6721-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6760-5p ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-15b-3p ; hsa-mir-3123 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-1227-3p ; hsa-mir-194-5p ; hsa-mir-6811-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-371a-3p ; hsa-mir-371b-3p ; hsa-mir-508-5p ; hsa-mir-651-5p ; hsa-mir-7977 ; hsa-mir-4266 ; hsa-mir-342-3p ; hsa-mir-383-3p ; hsa-mir-1228-3p ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-4284 ; hsa-mir-24-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1249556; hsa-mir-105-1/Downstream/983227;
Nearest TSS
ENST00000429181/Upstream/930; ENST00000617377/Downstream/330995;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/232, chrX-CpG: 123/Downstream/371220
Nearby gene
ZC4H2(-899) ;
Upstream sequence
AGCCTGATTCCTGATTCGTGGACAGACTCTCCCAGTGCCGTGCTCGCCCCTTTCCCCTCGCTCTGGCTCTGGCTCTCGCTCTCTCAGGAGGCTCAGCCTG
Downstream sequence
ACCGCGGGCTTCTCAGGAGCCCATTCCCCGGGCTGCTGTCGCTCCATGCCTCAAGGTTTGAACACATAGCTGGAGTGGCCCCTTACTTTTCAGTGTTGTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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