Basic Information
VIS ID
TVIS44003933
Fusion event
HTLV-1-TCF20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42636196/42240190 (Hg38)
End
42636196/42240190 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TCF20
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-205-5p ; hsa-mir-1247-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-433-3p ; hsa-mir-7154-5p ; hsa-mir-623 ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-6729-3p ; hsa-mir-6847-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-1178-5p ; hsa-mir-4779
Nearest miRNA
hsa-mir-1281/Upstream/316893; hsa-let-7a-3/Downstream/2960764;
Nearest TSS
ENST00000624155/Upstream/24748; ENST00000332965/Downstream/29563;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/86993, chr22-CpG: 180/Downstream/29256
Upstream sequence
tctaaaagctttagttatgaactaatttaactggcacagccacccacgaggtaggtacaattattatttccattttctagacaacgaaacagaggcagaa
Downstream sequence
tagtcatttgcttgacgtcacattgcaaacaaggggcagagctgggattcaaaaatcaggcgactggctgcagagatcatgctctAGATAGTGAGTCTTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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