VISDB - VIS Detail

Basic Information

VIS ID

TVIS44003951

Fusion event

HTLV-1-PSME4 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr2

Cytoband

p16.2

Reference genome

GRCh37/hg19

Start

54107247/53880110 (Hg38)

End

54107247/53880110 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA2S ; FRA2D ; FRA2H

Target gene

PSME4

miRNAs that regulate target gene

hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-1303 ; hsa-let-7e-5p ; hsa-mir-218-5p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-142-3p ; hsa-mir-4326 ; hsa-mir-6073 ; hsa-mir-20b-3p ; hsa-mir-4255 ; hsa-mir-1183 ; hsa-mir-651-3p

Nearest miRNA

hsa-mir-1301/Upstream/30905; hsa-mir-10b/Downstream/2102857;

Nearest TSS

ENST00000437798/Upstream/9150; ENST00000606082/Downstream/1398;

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/19981, chr2-CpG: 81/Downstream/90401

Upstream sequence

CCTTGGTGTGGAGGAAGAATATGGTGGAAGTAATTTAACCACATCTCCAAAATGGCAGGACATCCATAGCAAAGTAACTTAAGTTGGAAAATAAAAAATG

Downstream sequence

AGCAGTATAAGGGTATTTCTTTAGAGACAAAGAGGTGTGCAAAAGCTTAAAAGtggtaaacttgggctgggcagagtggcttatgcccatcatcctagca

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.