Basic Information
VIS ID
TVIS44003957
Fusion event
HTLV-1-RNF217 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
125407077/125085931 (Hg38)
End
125407077/125085931 (Hg38)
Orient
+
Location type
UTR3
Target gene
RNF217
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-4276 ; hsa-mir-205-5p ; hsa-mir-5190 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-138-2-3p ; hsa-mir-6507-5p ; hsa-mir-6833-5p ; hsa-mir-6124 ; hsa-mir-3190-3p ; hsa-mir-3148 ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-4280 ; hsa-mir-576-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-198 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-4530 ; hsa-mir-590-3p ; hsa-mir-338-3p ; hsa-mir-6818-3p ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-6895-3p ; hsa-mir-593-3p ; hsa-mir-6845-3p ; hsa-mir-942-5p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-10398/Upstream/5070674; hsa-mir-1202/Downstream/1398700;
Nearest TSS
ENST00000381078/Upstream/39331; ENST00000534368/Downstream/33118;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/122688, chr6-CpG: 34/Downstream/13666
Upstream sequence
aaatagaaaaatattcttactgtgctgtgactctttgtcattttattatatattaatagatacctttccataagcgtttaaatagatttacctcattctt
Downstream sequence
ttataaattactgcataatccattgtaggagtatactttaacttattgaattagtcccctgttgaatggactacaagattattttcacttctctattaca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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