Basic Information
VIS ID
TVIS44003965
Fusion event
HTLV-1-MALT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56341828/58674596 (Hg38)
End
56341828/58674596 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
MALT1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-548au-3p ; hsa-mir-3148 ; hsa-mir-6124 ; hsa-mir-605-3p ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-3714 ; hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-4777-3p ; hsa-mir-668-3p ; hsa-mir-875-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-182-5p ; hsa-mir-7150 ; hsa-mir-548aw ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4775 ; hsa-mir-6740-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-4735-5p ; hsa-mir-3613-3p ; hsa-mir-648 ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-590-3p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-26a-5p ; hsa-mir-181d-5p
Nearest miRNA
hsa-mir-1-2/Upstream/223438; hsa-mir-5011/Downstream/8406988;
Nearest TSS
ENST00000575820/Upstream/2389; ENST00000587438/Downstream/3018;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/2750, chr18-CpG: 27/Downstream/93862
Nearest cancer related gene
MALT1(OG, No orient, 0)
Upstream sequence
AAGGGTTGGAGAATTTGGGAACGTTAAGCTCATCCCTATGGAGATCAGAAGAATTAAACGGACTTTTTTTCAAAAAACAGCACTGGGAGCTTGGGGGCTG
Downstream sequence
GACAGTGAAGCAAGGTCAGCTGGGGATGCTTACTCTATTTAAGACAAAAAAGTTATTGTAAAGTGATTTCATGCTGTTGGGAGAAGATCTGTGATACTAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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