Basic Information
VIS ID
TVIS44003971
Fusion event
HTLV-1-KIZ integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
21165851/21185211 (Hg38)
End
21165851/21185211 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
KIZ
Nearest miRNA
hsa-mir-103a-2/Upstream/2714520; hsa-mir-1-1/Downstream/5022975;
Nearest TSS
ENST00000382410/Upstream/22321; ENST00000441136/Downstream/33054;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/58885, chr20-CpG: 90/Downstream/117787
Upstream sequence
TTTCTGTACTTTTATACTGAATCTATTTTGAATTTGGGTTGGAAGCTTTAGAATATTACCTTAACCTACAAGAGAGATGTGAGGAATAGTTCTGAGTCCC
Downstream sequence
CTATCTTTTATGGCTTTCAACTATTTTTCTCACTTTTTTTCTGACGGTTTTCCTTTGTCAGTGTAAATTCATTTTGATTTGCTTGTTATTTTGATGGACT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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