Basic Information
VIS ID
TVIS44003975
Fusion event
HTLV-1-CAMK2D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q26
Reference genome
GRCh37/hg19
Start
114574836/113653680 (Hg38)
End
114574836/113653680 (Hg38)
Orient
-
Location type
Intronic
Target gene
CAMK2D
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-484 ; hsa-let-7a-5p ; hsa-mir-30c-5p ; hsa-mir-185-5p
Nearest miRNA
hsa-mir-12113/Upstream/501318; hsa-mir-1305/Downstream/1003079;
Nearest TSS
ENST00000502981/Upstream/136037; ENST00000503557/Downstream/107388;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/947329, chr4-CpG: 86/Downstream/107233
Upstream sequence
GATGCCATTGAAAAAGACTTTTAATTGTCATTCATAAAACTATTAACTTTGTTTTCTCAGTAGATCAATTAACATTTACTCTGCATTAACTCTACTCTTC
Downstream sequence
TTTCCTATGTGATTTTGTTTCCAAGGGTTCAAAAACTGGAATATTGGTACAATAAACACATAAGGCAATTTACTCATTTATAAGTAAATACTGGGTATAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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