Basic Information
VIS ID
TVIS44003978
Fusion event
HTLV-1-TTLL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43483390/43087384 (Hg38)
End
43483390/43087384 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TTLL1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6516-5p ; hsa-mir-550b-2-5p ; hsa-mir-455-3p ; hsa-mir-7703 ; hsa-mir-6807-5p ; hsa-mir-1227-3p ; hsa-mir-6499-3p ; hsa-mir-1825 ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-4459 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-6785-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-25-5p ; hsa-mir-6894-5p ; hsa-mir-658 ; hsa-mir-6087 ; hsa-mir-544b ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p
Nearest miRNA
hsa-mir-1281/Upstream/1164087; hsa-let-7a-3/Downstream/2113570;
Nearest TSS
ENST00000624155/Upstream/11798; ENST00000216115/Downstream/1954;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/71880, chr22-CpG: 56/Downstream/1667
Upstream sequence
gaggccaagacaggtggatcacctgaggtcgggagttcgagaccagcctggctaacatggtgaaaccccgtctctactaaaaatacaaaattagctgcgc
Downstream sequence
gtggtggtgcacatctgtaatcccagctactcagaaggctgatgcacgagaatcacttgaacctgggaggtggaggttgcagtgagctggcatcacgcca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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