Basic Information
VIS ID
TVIS44003982
Fusion event
HTLV-1-CMIP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
81525386/81491781 (Hg38)
End
81525386/81491781 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16D
Target gene
CMIP
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-302a-5p ; hsa-let-7c-3p ; hsa-mir-3924 ; hsa-mir-550a-3p ; hsa-mir-200c-5p ; hsa-mir-3529-3p ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-1225/Upstream/106688; hsa-mir-11401/Downstream/42121;
Nearest TSS
ENST00000527434/Upstream/46611; ENST00000565029/Downstream/3568;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/46187, chr16-CpG: 39/Downstream/186478
Upstream sequence
CGTCCCCAACTCCACAATCACGTGGATCTGGATCATTTGGCACCCTTCCCTGTCTGAACTCGGGAGCTGGATGGATTTGGCTACTGAGGATTGCTTGTAT
Downstream sequence
CGATTTTCCACTTATTCCTCTTGGTCTTGGCCCATCTGTACACATACTTTTATGTCATTACAGGCACAGTGAACATGCTGGTTTCTTTCCATTTTCTCCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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