Basic Information
VIS ID
TVIS44003989
Fusion event
HTLV-1-CARS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
111343063/110690716 (Hg38)
End
111343063/110690716 (Hg38)
Orient
-
Location type
Intronic
Target gene
CARS2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-30d-5p
Nearest miRNA
hsa-mir-1267/Upstream/349687; hsa-mir-4502/Downstream/2572204;
Nearest TSS
ENST00000623511/Upstream/7577; ENST00000464141/Downstream/14900;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/11690, chr13-CpG: 73/Downstream/15017
Upstream sequence
CATCCTCACCACTACAAACACAACtgtgcacaggtcactttgcagcagcccaagtgtgcctgtgagctacactcgtaggcaggagacagagggcacaggc
Downstream sequence
tcatggacttggccgctcctgcaagctgccttccaggaaagctgtgccagctacacccgaccagcaacacctggaggtgtctgtcttcctctgccctcac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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