Basic Information
VIS ID
TVIS44003991
Fusion event
HTLV-1-GAS6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
114562794/113859821 (Hg38)
End
114562794/113859821 (Hg38)
Orient
+
Location type
Intronic
Target gene
GAS6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1285-5p ; hsa-mir-1304-3p ; hsa-mir-3691-3p ; hsa-mir-4257 ; hsa-mir-5008-5p ; hsa-mir-5699-5p ; hsa-mir-6847-5p ; hsa-mir-874-5p
Nearest miRNA
hsa-mir-1267/Upstream/596822; hsa-mir-4502/Downstream/384684;
Nearest TSS
ENST00000623511/Upstream/17331; ENST00000608651/Downstream/4194;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/16226, chr13-CpG: 163/Downstream/3013
Upstream sequence
atctgtgctggtgtccatgtgtgaatgtgtgtgcatgtgtctgtgtgtgggagtgtgCTGCAGCCTCTGTCAAGGCAGGGCAGGGGAGGTCTCAGCCTGG
Downstream sequence
CCATCACCTTCCCCACCAGGCGCCCCCACATTGTACAGCCCTCCCCTCCAACAGGGACCTCCCTTTAGGCCATCCCAACATCTGGGCCTGTGTCCCAGCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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