Basic Information
VIS ID
TVIS44004003
Fusion event
HTLV-1-RUFY3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
71576674/70710957 (Hg38)
End
71576674/70710957 (Hg38)
Orient
+
Location type
Intronic
Target gene
RUFY3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-505-3p
Nearest miRNA
hsa-mir-12113/Upstream/4434029; hsa-mir-1243/Downstream/5862611;
Nearest TSS
ENST00000502981/Upstream/6156; ENST00000513597/Downstream/11038;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5048, chr4-CpG: 122/Downstream/127990
Upstream sequence
ttcaagaccagcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaaaattagccaggtatggtagtgcacgcctgtaatcccagctactg
Downstream sequence
gggaagctgaggcaggagaaccgcttgaacccaggaggcagaggttacagtgagccaagatccgccactacactccagcctgggccacagagcaagactc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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