Basic Information
VIS ID
TVIS44004007
Fusion event
HTLV-1-KDM5D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrY
Cytoband
q11.223
Reference genome
GRCh37/hg19
Start
21888125/19726239 (Hg38)
End
21888125/19726239 (Hg38)
Orient
+
Location type
Intronic
Target gene
KDM5D
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-12120/Upstream/6246973;
Nearest TSS
ENST00000430575/Upstream/3772; ENST00000465253/Downstream/18472;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/158569, chrY-CpG: 16/Downstream/849700
Upstream sequence
gattcctcaaggatctagaactagaaataccatttgacccagcaatcccattactgggtatacacccagaggattataaatcattctactataaagacac
Downstream sequence
atgcaaatgtatgtttaatgcagcactgttcacaatagcaaagacttggaaccaacccaaatgtccatcaatgatagactggattaaaaaaatgttgcac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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