VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004010

Fusion event

HTLV-1-PSPH integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

p11.2

Reference genome

GRCh37/hg19

Start

56107355/56039662 (Hg38)

End

56107355/56039662 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA7A

Target gene

PSPH

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-296-3p ; hsa-mir-4444 ; hsa-mir-5696 ; hsa-mir-340-5p ; hsa-mir-496 ; hsa-mir-3691-3p ; hsa-mir-4729 ; hsa-mir-3163 ; hsa-mir-1208 ; hsa-mir-1303 ; hsa-mir-1304-3p ; hsa-mir-3658 ; hsa-mir-483-5p ; hsa-mir-6760-3p ; hsa-mir-7856-5p

Nearest miRNA

hsa-mir-1183/Upstream/11157862; hsa-mir-10399/Downstream/916123;

Nearest TSS

ENST00000635602/Upstream/5490; ENST00000493855/Downstream/11626;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/74452, chr7-CpG: 105/Downstream/11690

Upstream sequence

gtcaggagatcgagaccatcctggccaacatggtgaaagcccatctctactaaaatacaaaaaattagctgggcatggtagtacgtgcctgtagtcccac

Downstream sequence

ctacttgtgaggctgaagcagggaaatcgcttgaacccaggaagtggaggttgcagtaagccgagattgcaccactgcactccaccctggtgacagagaa

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.