Basic Information
VIS ID
TVIS44004020
Fusion event
HTLV-1-BRSK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
1465067/1443837 (Hg38)
End
1465067/1443837 (Hg38)
Orient
-
Location type
Intronic
Target gene
BRSK2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4467 ; hsa-mir-4767 ; hsa-mir-8072 ; hsa-mir-3960 ; hsa-mir-1827 ; hsa-mir-4285 ; hsa-mir-6727-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-4508 ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-3141 ; hsa-mir-4433b-5p ; hsa-mir-6789-3p ; hsa-mir-6832-3p
Nearest miRNA
hsa-mir-210/Upstream/187167; hsa-let-7a-2/Downstream/415627;
Nearest TSS
ENST00000527297/Upstream/1392; ENST00000531932/Downstream/6821;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/143, chr11-CpG: 72/Downstream/1237
Upstream sequence
CCAGGTGTGTGGGTCGGTGCCCAGGTGTGTGGACGTGTGCACAGGTGTCGGCTTGTGTTCAGGTGTGGGTGACCAAATGTGGGCCCATGGCCGTGTGTGG
Downstream sequence
GTGCCCAGGTGAGTGTTCAAGTGTGTGTGCGCACCCAGGTGTGGGAGTGCCCAGGCGTGTGTGGGCTCGTGTTCAGGTGTGTGGGTGCACAAATGTAGGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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