Basic Information
VIS ID
TVIS44004025
Fusion event
HTLV-1-AOX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
201456619/200591896 (Hg38)
End
201456619/200591896 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
AOX1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10b/Upstream/11458785; hsa-mir-1244-1/Downstream/6191338;
Nearest TSS
ENST00000437798/Upstream/3722; ENST00000485965/Downstream/17313;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/5592, chr2-CpG: 134/Downstream/219370
Upstream sequence
gacgatattgcgggtaccaagagtggaggcagggagaactctcaggcaggtcttataatcattcagacaataggtgatatgggctcatgggcagtgacag
Downstream sequence
tagaagagaaaggagtttagaggaacattggaagcccaagtggaagaacttggtgacactgattgtggtggattggaaaaaaaaaagttgaaaatagctc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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