Basic Information
VIS ID
TVIS44004032
Fusion event
HTLV-1-SERINC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
79466979/80171156 (Hg38)
End
79466979/80171156 (Hg38)
Orient
-
Location type
Intronic
Target gene
SERINC5
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-16-5p ; hsa-mir-3926 ; hsa-mir-4753-5p ; hsa-mir-6796-3p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-548an ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-10397/Upstream/7292493; hsa-mir-103a-1/Downstream/2668999;
Nearest TSS
ENST00000502646/Upstream/3976; ENST00000511881/Downstream/84042;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/135491, chr5-CpG: 103/Downstream/84394
Upstream sequence
ctggagtgctgtggtgtgatcttggctcattgcaacccccgcctcccaggttcaagtaattctctgcctcagcctccttagtagctgggattacaggtat
Downstream sequence
ccaccaccatgccgggctaattttgtatttttagtaaagacggggtttcaccatcttggccaggctggtcttgaactcctgacctcgtgatccacccacc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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