Basic Information
VIS ID
TVIS44004034
Fusion event
HTLV-1-LOXL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
23242886/23385373 (Hg38)
End
23242886/23385373 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOXL2
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-29b-3p ; hsa-mir-218-5p ; hsa-mir-410-5p ; hsa-mir-4465 ; hsa-mir-498 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-4679 ; hsa-mir-3691-3p ; hsa-mir-4677-3p ; hsa-mir-5697 ; hsa-mir-511-3p ; hsa-mir-595 ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-29b-2-5p ; hsa-mir-4507 ; hsa-mir-3940-5p ; hsa-mir-376a-5p ; hsa-mir-6793-5p ; hsa-mir-194-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p
Nearest miRNA
hsa-mir-124-1/Upstream/1140336; hsa-mir-10400/Downstream/1568423;
Nearest TSS
ENST00000518652/Upstream/14247; ENST00000521021/Downstream/18703;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/96880, chr8-CpG: 120/Downstream/17556
Upstream sequence
ttcactcctgttgcccaggctggagtgcagtggtgtgatctcggcctactgcaacctctgcgtcccaggttcaagcaattctcctgcctcagcctcccaa
Downstream sequence
gtagctgggattacaggcacacaccaccacacccagctaatttttttttttttttttggtattttcagtagagaaggggtttcaccatgttggctagact
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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