Basic Information
VIS ID
TVIS44004036
Fusion event
HTLV-1-PKN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
131475122/128712843 (Hg38)
End
131475122/128712843 (Hg38)
Orient
-
Location type
Intronic
Target gene
PKN3
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-1226-3p ; hsa-mir-615-3p ; hsa-mir-324-3p
Nearest miRNA
hsa-let-7a-1/Upstream/320129; hsa-mir-12126/Downstream/1156762;
Nearest TSS
ENST00000422679/Upstream/10320; ENST00000485301/Downstream/274;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/9292, chr9-CpG: 58/Downstream/11093
Upstream sequence
GACAACGTGGCTCCTCACCTGGGAGTGTCCAGGTCGGAGGCCTCCTAGGGTGTCATCGGGGTCCAAGGGTACCCTTTGGGGGGCTCATGGTGCTTGGGAG
Downstream sequence
CTGCAGGACAGTCAGCAGGCTCCAGTCTAGGCACTCTAGGCCGCCACACTGAGTGAGGTTCCTCAGGTAACTGCCCTGGCCTCAGGTGGGTACGGTCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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