Basic Information
VIS ID
TVIS44004046
Fusion event
HTLV-1-CDC25A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
48202535/48161045 (Hg38)
End
48202535/48161045 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDC25A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-15a-5p ; hsa-let-7c-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-34a-5p ; hsa-let-7b-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-193b-3p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-let-7i-5p ; hsa-mir-92a-3p ; hsa-mir-365a-3p ; hsa-mir-141-3p ; hsa-mir-584-3p ; hsa-mir-195-5p ; hsa-mir-497-5p ; hsa-mir-3138 ; hsa-mir-5693 ; hsa-mir-194-3p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-3120-3p ; hsa-mir-651-3p ; hsa-mir-4803 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-668-5p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-1281 ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-5584-3p ; hsa-mir-624-5p ; hsa-mir-4323 ; hsa-mir-140-3p ; hsa-mir-3121-3p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-26a-1-3p
Nearest miRNA
hsa-mir-12127/Upstream/311416; hsa-let-7g/Downstream/35519;
Nearest TSS
ENST00000440867/Upstream/71773; ENST00000296435/Downstream/13708;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/71639, chr3-CpG: 111/Downstream/26542
Nearest cancer related gene
CDC25A(OG, No orient, 0)
Upstream sequence
gttcgagaccagcctggccaagatagtgaaaccctgtgtctactaaaactacaaaaaattagctgggcgtggtggcaggtgcctgtaatcccagctactt
Downstream sequence
gggaggctgaggcagagaaatgcttgaacccgggaggaggaggctgcagtgagccgagattgtgccactgcattccagcctgggcgaaagggcgagattc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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