Basic Information
VIS ID
TVIS44004068
Fusion event
HTLV-1-FAM168A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73285106/73574061 (Hg38)
End
73285106/73574061 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
FAM168A
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-10a-5p ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-555 ; hsa-mir-765 ; hsa-mir-5702 ; hsa-mir-6861-5p ; hsa-mir-6742-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-3139 ; hsa-mir-708-5p ; hsa-mir-28-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-6801-5p ; hsa-mir-4266 ; hsa-mir-766-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-4722-5p ; hsa-mir-6731-5p ; hsa-mir-1827 ; hsa-mir-4768-3p ; hsa-mir-4259 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6888-5p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-10392/Upstream/790469; hsa-let-7a-2/Downstream/825176;
Nearest TSS
ENST00000527297/Upstream/105569; ENST00000536527/Downstream/24036;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/196824, chr11-CpG: 63/Downstream/23693
Upstream sequence
AAGGGGCAGGGGTGGGGgcagggcatggcgttgcacacctgtggtcccagctactcaggaggcgaggcagggggatcactaagcccaggaggtggaggca
Downstream sequence
acagtgagccatgagcccaccactgtactccagcctgggtgacagagcaagaccctgtctcaaaaaaaaaaGTAATTAATTCTCTAAGCCCCACTTAATA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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