Basic Information
VIS ID
TVIS44004069
Fusion event
HTLV-1-CDK5RAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.2
Reference genome
GRCh37/hg19
Start
123296661/120534383 (Hg38)
End
123296661/120534383 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK5RAP2
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-324-3p ; hsa-mir-149-5p
Nearest miRNA
hsa-let-7a-1/Upstream/289333; hsa-mir-12126/Downstream/1585699;
Nearest TSS
ENST00000422679/Upstream/1828; ENST00000437707/Downstream/2054;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/39287, chr9-CpG: 41/Downstream/45465
Upstream sequence
gcctctggacttccactcgcactgttccttTACTTTCCTTTCTCTGTCCAAGTAATTCTTCCTCTTCCTAGTACTTCTCCCGGGAAGCTTTTCCTAATCC
Downstream sequence
CTCTAAACTGAATTAGATATATGTTAACCCAGCATTGATCCTACTTAGCCCTTATCATCCTGCTCCTCCCTCCACCCCTCCCACCCTGCTGGATGATAAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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