VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004084

Fusion event

HTLV-1-ABLIM1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr10

Cytoband

q25.3

Reference genome

GRCh37/hg19

Start

116552412/114792653 (Hg38)

End

116552412/114792653 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

ABLIM1

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-122-5p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-320a ; hsa-mir-100-5p ; hsa-mir-34a-5p ; hsa-mir-5581-3p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-610 ; hsa-mir-556-5p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-4480 ; hsa-mir-6845-3p ; hsa-mir-1226-3p ; hsa-mir-512-3p ; hsa-mir-216b-5p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-548c-3p ; hsa-mir-8485 ; hsa-mir-4540 ; hsa-mir-6758-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6838-3p ; hsa-mir-153-3p ; hsa-mir-4276 ; hsa-mir-4766-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-3908 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-6727-3p ; hsa-mir-1281 ; hsa-mir-4763-3p ; hsa-mir-6836-5p ; hsa-mir-1207-5p ; hsa-mir-6132 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-3918 ; hsa-mir-1306-5p ; hsa-mir-6895-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-411-5p ; hsa-mir-3202 ; hsa-mir-4533

Nearest miRNA

hsa-mir-107/Upstream/618474; hsa-mir-202/Downstream/2034835;

Nearest TSS

ENST00000439456/Upstream/27865; ENST00000369246/Downstream/29091;

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/23938, chr10-CpG: 122/Downstream/28919

Nearby gene

LOC101927692(No orient, 12750)

Upstream sequence

ggacaccactgctttgtggttcccctacctcctgctggctgctccttcttctttctgtgggattctcctcttctccttctcaggtcttgatcctcttctt

Downstream sequence

ccctccatccatgaggctccttgggtaaaccaatccaatcccatgactgttaatactgttcatatgttgatgattttcaaatttatatttccagcttgga

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.