Basic Information
VIS ID
TVIS44004085
Fusion event
HTLV-1-LUZP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
24899340/24877794 (Hg38)
End
24899340/24877794 (Hg38)
Orient
+
Location type
Intronic
Target gene
LUZP2
miRNAs that regulate target gene
hsa-mir-653-5p ; hsa-mir-5585-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-205-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-652-5p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548s ; hsa-mir-3165 ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-7162-3p ; hsa-mir-6078 ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-340-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p ; hsa-mir-6827-3p
Nearest miRNA
hsa-mir-210/Upstream/1458604; hsa-let-7a-2/Downstream/2637176;
Nearest TSS
ENST00000527297/Upstream/148654; ENST00000528970/Downstream/13971;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/380602, chr11-CpG: 29/Downstream/1454196
Upstream sequence
ctaactatatttttgtactcattaaccatccccacctccctctcacatcactcccacaccccaactactcttctcaggctgtggtaagcatccttctact
Downstream sequence
gtcaatctccatgagttcaattgttttaatttttagtcctcacaaatagatgagaacacgtgatatttgtctttcagtgcctggcttattttacttaata
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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