Basic Information
VIS ID
TVIS44004087
Fusion event
HTLV-1-ADCY3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
25051407/24828538 (Hg38)
End
25051407/24828538 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADCY3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1301-3p ; hsa-mir-1296-5p ; hsa-mir-877-5p
Nearest miRNA
hsa-mir-3125/Upstream/5480033; hsa-mir-10b/Downstream/500102;
Nearest TSS
ENST00000437798/Upstream/2928; ENST00000421904/Downstream/3195;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/34780, chr2-CpG: 129/Downstream/91065
Upstream sequence
aacacaattagcaagcagaaaagccaaaagtaggagccaagtctttaggcttcaaatccaacatgttcttccccatatcacactgttgctTCAGGAGGGG
Downstream sequence
CCACGGGACcatgagccccactcacagcctccccgtgatgacagctagtctctgcccaaatccttccattggggggatgttcactgccttctggattctt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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