Basic Information
VIS ID
TVIS44004091
Fusion event
HTLV-1-LAMB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
209800445/209627100 (Hg38)
End
209800445/209627100 (Hg38)
Orient
-
Location type
Intronic
Target gene
LAMB3
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-124-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3590; hsa-mir-1182/Downstream/2450513;
Nearest TSS
ENST00000473358/Upstream/8302; ENST00000367029/Downstream/24234;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1091, chr1-CpG: 75/Downstream/47998
Upstream sequence
GTGGACCCTGCCTCACAGCCTCTGCCTTACCCTGGTGTCAGGGACTGTGTCCTAGATTCCTGGTCCACAGGTAGAATCCAGGGCTCATGGCCACCTCCAG
Downstream sequence
AGCTGCTGTGCCCACAAAACAAGGGCTCCCACTCAGAGATGAGCCTTGAAGTCAAGGCCCAGCATAGGCCCTTCAGAAGGTGTGGTGCATATGGTATTAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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