Basic Information
VIS ID
TVIS44004098
Fusion event
HTLV-1-PRMT8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
3579479/3470313 (Hg38)
End
3579479/3470313 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRMT8
miRNAs that regulate target gene
hsa-mir-330-3p ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-2276-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3939 ; hsa-mir-3925-5p
Nearest miRNA
hsa-mir-3649/Upstream/1809933; hsa-let-7i/Downstream/3493386;
Nearest TSS
ENST00000382841/Upstream/6727; ENST00000543701/Downstream/20923;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/103825, chr12-CpG: 196/Downstream/20574
Upstream sequence
AACATCCCCATAGTCCTCAGGATCCCCTGAGAGGGGCCGAGTCAGAGGGTGTCAAGGCCTCCAGTCCTCTGGGCATCCAGGGCCTCATGGCAACTGCAGC
Downstream sequence
AATTGTTCTCACTTTGGTTGTTTTTCCATAGGACTCAATGTGCTCTTACACAGGGACTCAGGACAGTGCTGAGTCCAGGTGGAGGGAAGAGGTCGGATGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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