Basic Information
VIS ID
TVIS44004104
Fusion event
HTLV-1-XPO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p15
Reference genome
GRCh37/hg19
Start
61713311/61486176 (Hg38)
End
61713311/61486176 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
XPO1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-1236-3p ; hsa-mir-125a-5p ; hsa-mir-23b-3p ; hsa-mir-92a-3p ; hsa-mir-17-3p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-382-5p ; hsa-mir-485-5p ; hsa-mir-4495 ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-224-5p
Nearest miRNA
hsa-mir-1301/Upstream/1098731; hsa-mir-10b/Downstream/719650;
Nearest TSS
ENST00000437798/Upstream/218; ENST00000425779/Downstream/2487;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/14511, chr2-CpG: 64/Downstream/52095
Upstream sequence
AAATCTTGTGTTTGTATTAGGGTTTCCTACGTCAAAACAGTTTTTAGCAAAAGAAAGCAGGAAATCACAATGGGTTGGGAAGTCTCATGGACACACTGTC
Downstream sequence
ATTCAAGACtttttttttttgagacagtctcactgtcactcagaccagagtgcagtggcaaatctctgctcactgcaacctccacctcccaggttcaagc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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