VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004126

Fusion event

HTLV-1-CCDC18 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

p22.1

Reference genome

GRCh37/hg19

Start

93731313/93265756 (Hg38)

End

93731313/93265756 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA1D

Target gene

CCDC18

miRNAs that regulate target gene

hsa-mir-192-5p ; hsa-mir-136-5p ; hsa-mir-3121-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-4639-3p ; hsa-mir-501-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-3161 ; hsa-mir-6844 ; hsa-mir-103a-2-5p ; hsa-mir-100-3p

Nearest miRNA

hsa-mir-101-1/Upstream/6908069; hsa-mir-11399/Downstream/581076;

Nearest TSS

ENST00000473358/Upstream/11239; ENST00000481583/Downstream/80132;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/84842, chr1-CpG: 66/Downstream/79905

Upstream sequence

Caacaggctttaaaccaacaaagatcaaaagagaccaagaaggccattacataatggtaaagggatcaattcaacaagaagagctaactgtcctaaatat

Downstream sequence

atatgcacccaatacaggagcacccagattcataagtcaagtccttagagacctacaaagagacttagactcccacacaataataatgggagactttaac

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.