Basic Information
VIS ID
TVIS44004131
Fusion event
HTLV-1-CLMP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
122981093/123110385 (Hg38)
End
122981093/123110385 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLMP
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3685 ; hsa-mir-20a-3p ; hsa-mir-1283 ; hsa-mir-155-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4252 ; hsa-mir-4520-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-3193 ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-596 ; hsa-mir-508-5p ; hsa-mir-122-3p ; hsa-mir-382-3p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4635 ; hsa-mir-324-5p ; hsa-mir-877-3p
Nearest miRNA
hsa-let-7a-2/Upstream/958077; hsa-mir-3167/Downstream/271055;
Nearest TSS
ENST00000527297/Upstream/12419; ENST00000531681/Downstream/78417;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/47290, chr11-CpG: 115/Downstream/84333
Upstream sequence
tctactaaaaacacaaaaattagccggccgtgttggcaggcacttgtaattccagctacttgggaggctgagatgggagaatcgcttgaacccgagaggt
Downstream sequence
ggaagttgccatgagccctgattgtgtcactgcacaccagcctgggtgacagagcgagactccgtcagaaaaaaaaaaaaaaaattagccaggtgtggta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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