Basic Information
VIS ID
TVIS44004144
Fusion event
HTLV-1-NPHP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
110921523/110163946 (Hg38)
End
110921523/110163946 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
NPHP1
miRNAs that regulate target gene
hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-6778-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-6131 ; hsa-mir-3663-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/77423; hsa-mir-10b/Downstream/120907;
Nearest TSS
ENST00000437798/Upstream/19398; ENST00000456683/Downstream/41015;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/47936, chr2-CpG: 22/Downstream/40877
Upstream sequence
ggtgaggtttcgctgtgttgactaggctggtcttgaactcttgaccccaggtgatccacccgccttggcctcccaaagtgctgggattacaggtgtgagc
Downstream sequence
cactgtgcccATGAGCCACTGTGCCCGGCCTGTAATTTTTTTTTAATGACAGAATTATGGATCATTTCTCCTTTAAAAAAATGTAATTAATTACtttttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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