Basic Information
VIS ID
TVIS44004153
Fusion event
HTLV-1-ADGRA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
37694280/37836762 (Hg38)
End
37694280/37836762 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRA2
miRNAs that regulate target gene
hsa-mir-138-5p
Nearest miRNA
hsa-mir-124-1/Upstream/7879414; hsa-mir-10400/Downstream/3434286;
Nearest TSS
ENST00000518652/Upstream/39506; ENST00000338825/Downstream/13076;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/38180, chr8-CpG: 110/Downstream/4566
Upstream sequence
TCCATCCCTCATGCCGTCACCAGATTCACCTTCTGCAAACTGCACTTTGCACGTCAGAGAGCCCCTTCAAAGTCTTGGGTTGTTTCCCATCATCAGGACG
Downstream sequence
TCTGCCTCCCTCCATGAGCCCTCTAGGGTCCTAGCGATGTGGCTGTACCCCCTTTGCCCAGCCAGAAGGCACTGCCACCCCACCGTGGGTTCCATCCTGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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