VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004155

Fusion event

HTLV-1-RFX3 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr9

Cytoband

p24.2

Reference genome

GRCh37/hg19

Start

3475082/3475082 (Hg38)

End

3475082/3475082 (Hg38)

Orient

+

Location type

Intronic

Target gene

RFX3

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-128-3p ; hsa-mir-615-3p ; hsa-mir-342-3p ; hsa-mir-4698 ; hsa-mir-892c-5p ; hsa-mir-4428 ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-1264 ; hsa-mir-4668-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-3977 ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-222-5p

Nearest miRNA

hsa-mir-1302-9/Upstream/3444801; hsa-let-7a-1/Downstream/1375215;

Nearest TSS

ENST00000422679/Upstream/79486; ENST00000430387/Downstream/14334;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/293215, chr9-CpG: 89/Downstream/50939

Upstream sequence

tagctactcgggaggctgaggcaggaagattgcttgagcccaggtgatctaggctgcagtgagctataattgtgccactgcactaacagcctgggcaaca

Downstream sequence

gagcaagaccctgtctccaaaaaaaaaaaaagaaagaaaaagaaaaaGGAAGGAAGGAAGGAAGGTAGGTTGCCAACTATAAACAGTTATAAATGGATGC

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.