Basic Information
VIS ID
TVIS44004159
Fusion event
HTLV-1-MTG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
135219631/133406127 (Hg38)
End
135219631/133406127 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
MTG1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-642a-5p ; hsa-mir-1236-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-877-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4323 ; hsa-mir-1224-3p ; hsa-mir-634 ; hsa-mir-6868-3p ; hsa-mir-4758-3p
Nearest miRNA
hsa-mir-107/Upstream/34464;
Nearest TSS
ENST00000439456/Upstream/4704; ENST00000475114/Downstream/18445;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2775, chr10-CpG: 15/Downstream/13287
Upstream sequence
tttaactagggtgagatgaaatctcattgtggttttgatttgcatttctctggtgattagtcatgttgagcattttttcatacacttgttggccatttgt
Downstream sequence
atgtcttcttttgagaaataattattcagatcttctgtccatttttaaatagttatgtggttttttttgctgttgagttgaattgcttatataatctggt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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