Basic Information
VIS ID
TVIS44004160
Fusion event
HTLV-1-KCNAB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q25.31
Reference genome
GRCh37/hg19
Start
155892108/156174319 (Hg38)
End
155892108/156174319 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
KCNAB1
miRNAs that regulate target gene
hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-144-5p ; hsa-mir-3613-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-4282 ; hsa-mir-3606-3p
Nearest miRNA
hsa-let-7g/Upstream/4608324; hsa-mir-1224/Downstream/3108327;
Nearest TSS
ENST00000440867/Upstream/31357; ENST00000496923/Downstream/53564;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/302506, chr3-CpG: 29/Downstream/116883
Upstream sequence
GTTTTACTCAAAATAATTTTAGGAATTAAATACTTGGTATTTTCTCTCTTTGTTCCCTTCAAGCAATAATTAATTTTTAGTGGTTTGTTCTTGGGTAGGA
Downstream sequence
ATTAGAAACATTATGTAGCTGACAGAGGGCTACATGCAGAGCTTATAAGGAGGAGCTGCTTTCTGCAGCCAGTTTCTTGATGAGAATTCAGCAGGAGGAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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