Basic Information
VIS ID
TVIS44004164
Fusion event
HTLV-1-DLG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
83864039/84152996 (Hg38)
End
83864039/84152996 (Hg38)
Orient
+
Location type
Intronic
Target gene
DLG2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10392/Upstream/2262160; hsa-let-7a-2/Downstream/2125337;
Nearest TSS
ENST00000527297/Upstream/427593; ENST00000534275/Downstream/14006;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/866503, chr11-CpG: 24/Downstream/1475303
Upstream sequence
tgttagctgttttgtagacttgattatatagttgccctatagggtctgtgctatgcacttaagtgtgttgctgtggtaacaggtatcattctttgatttc
Downstream sequence
tgtttagaactccctcaaggacctcttgtatggctgatctggtggtaacaaattcccttacgcttgtctggaaaggattttatttctcctttgtgtatga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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