Basic Information
VIS ID
TVIS44004186
Fusion event
HTLV-1-SYNJ1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
34016658/32644348 (Hg38)
End
34016658/32644348 (Hg38)
Orient
-
Location type
Intronic
Target gene
SYNJ1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-32-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-10a-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-let-7c/Upstream/2268970; hsa-mir-3197/Downstream/906314;
Nearest TSS
ENST00000624081/Upstream/2403; ENST00000458479/Downstream/1362;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/31208, chr21-CpG: 102/Downstream/83057
Upstream sequence
GCTGTAATGCTGAAATAATTTAGCTATTCTTATCACACGCAGTCATTAAGATCTACACACAGGCAAAGTCAGTCTGTAGTAAGACCTGAATTGCTCAGCC
Downstream sequence
ATGTCACTAGGCAAGCTACAATAGAAACAGACCAGGCTACACATGCACAGTGAGCCTTAGTAACACTGGATTTGTAAAAGTTCTTCTGAGGAATTGTGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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