Basic Information
VIS ID
TVIS44004189
Fusion event
HTLV-1-LRFN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
39804272/39313632 (Hg38)
End
39804272/39313632 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LRFN1
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-4313 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-7108-3p ; hsa-mir-6887-3p ; hsa-mir-3186-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-361-3p ; hsa-mir-6793-3p ; hsa-mir-6879-3p ; hsa-mir-3620-3p ; hsa-mir-6865-3p
Nearest miRNA
hsa-mir-10395/Upstream/3968005; hsa-let-7e/Downstream/95991;
Nearest TSS
ENST00000633603/Upstream/17307; ENST00000601613/Downstream/1704;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5022, chr19-CpG: 117/Downstream/349
Upstream sequence
aaacaaacaaataaataaatgtcactgtaaatgtgtgtgtgtgtttcatgctccaaaatgtttaactgaagaggtgcacaatcagaTTGTTGTGGGGAGC
Downstream sequence
AGTGATATCgaccatgagccccatgagggcagggttcatgctgagctcagtcactgttaggactccagtgcccagccctggtcgggttcatgtaggtgct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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