Basic Information
VIS ID
TVIS44004190
Fusion event
HTLV-1-ZDHHC14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
158027179/157606147 (Hg38)
End
158027179/157606147 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZDHHC14
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-130b-3p ; hsa-mir-587 ; hsa-mir-5581-3p ; hsa-mir-3140-3p ; hsa-mir-6872-3p ; hsa-mir-302f ; hsa-mir-451a ; hsa-mir-6511b-5p ; hsa-mir-676-5p ; hsa-mir-6811-5p
Nearest miRNA
hsa-mir-10398/Upstream/76947; hsa-mir-1913/Downstream/1003560;
Nearest TSS
ENST00000381078/Upstream/13138; ENST00000517432/Downstream/23242;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12923, chr6-CpG: 26/Downstream/66631
Upstream sequence
ATATGAAGATCGCATTACTCTCCTGAAATTATACTACCTGCACATTTTAGTTTTCAGGATAACACAGGTCTCTATGCCTCAGACCGGGCATTTTCCCCTT
Downstream sequence
CACGGTTCCCATGAGCCCCTTAAGATCTGAGGAGAGTCTGGAAgcggtggctcatgcctgtaatccaagcactttgggaggccgaggtgggtggatcagc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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