Basic Information
VIS ID
TVIS44004193
Fusion event
HTLV-1-VSIR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
73517982/71758225 (Hg38)
End
73517982/71758225 (Hg38)
Orient
-
Location type
Intronic
Target gene
VSIR
miRNAs that regulate target gene
hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6835-5p ; hsa-mir-6752-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-6081 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-922 ; hsa-mir-759 ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-16-1-3p
Nearest miRNA
hsa-mir-1265/Upstream/4354815; hsa-mir-107/Downstream/32522;
Nearest TSS
ENST00000439456/Upstream/595; ENST00000642965/Downstream/3719;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/96280, chr10-CpG: 49/Downstream/15109
Upstream sequence
gagttcgagaccagcctgaccaacatggCTCTGACCAAAATGCATGTTCTAATTTTGCTCTTGGCCTGTTTGTTGGTTTGAAAAAAGGGTAGCTGAGTAA
Downstream sequence
AAAGTCACTGTAGCCTTTGAGTTGGGTTTTGTTGGGTCCGTGGTTTAGCTGATCCCCATTCCGGCTTAGGTCCTCGTGCATGTCCTCCTGGATGCCTTTG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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