Basic Information
VIS ID
TVIS44004202
Fusion event
HTLV-1-HDAC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p35.1
Reference genome
GRCh37/hg19
Start
32792005/32326404 (Hg38)
End
32792005/32326404 (Hg38)
Orient
+
Location type
Intronic
Target gene
HDAC1
miRNAs that regulate target gene
hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-34a-5p ; hsa-mir-24-3p ; hsa-mir-671-5p ; hsa-mir-615-3p ; hsa-mir-92a-3p ; hsa-mir-30a-5p ; hsa-mir-874-3p ; hsa-mir-520h
Nearest miRNA
hsa-mir-12136/Upstream/239397; hsa-mir-101-1/Downstream/1005989;
Nearest TSS
ENST00000473358/Upstream/34243; ENST00000484305/Downstream/785;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/33971, chr1-CpG: 148/Downstream/8854
Nearest cancer related gene
HDAC1(TSG, No orient, 0)
Upstream sequence
gtgtatgtcaccacgcccagctaaattttttcgtatttttaatagagatgaggtttaaccatgttggccaggctggtatcgaactcttgacctcaggtga
Downstream sequence
tgtgcccgccttggcctcccaaacttctgggattacaggtgtgagccaccgcgcatggccTATCTTTGGTATTTtttcaaagttccttgaccatgagcca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate