Basic Information
VIS ID
TVIS44004204
Fusion event
HTLV-1-ETFA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
76567471/76275130 (Hg38)
End
76567471/76275130 (Hg38)
Orient
+
Location type
Intronic
Target gene
ETFA
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-18a-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10393/Upstream/512815; hsa-mir-11181/Downstream/2934658;
Nearest TSS
ENST00000557528/Upstream/43732; ENST00000558437/Downstream/8711;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/82891, chr15-CpG: 51/Downstream/36092
Upstream sequence
gggagccatagacaatacaactaacaacctccaaaaacgcacagcctcaccaccactatcttgagtcagccaggactaatcacaccctgcccttcattat
Downstream sequence
gtctgtccccataagccccaaactcaaaggttatccttcataacccatacactgatccccataatgctctgcatgctccctaacctgcaccaatctccca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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