Basic Information
VIS ID
TVIS44004211
Fusion event
HTLV-1-WNK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
96016141/93253859 (Hg38)
End
96016141/93253859 (Hg38)
Orient
+
Location type
Intronic
Target gene
WNK2
miRNAs that regulate target gene
hsa-mir-222-5p ; hsa-mir-4654 ; hsa-mir-4769-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-5196-5p ; hsa-mir-4493 ; hsa-mir-4747-5p ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936 ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-760 ; hsa-mir-3160-5p ; hsa-mir-3194-3p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-4267
Nearest miRNA
hsa-mir-101-2/Upstream/725801; hsa-let-7a-1/Downstream/340982;
Nearest TSS
ENST00000422679/Upstream/18936; ENST00000464625/Downstream/2867;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/6040, chr9-CpG: 35/Downstream/38918
Nearest cancer related gene
WNK2(TSG, No orient, 0)
Upstream sequence
GAGTGGGGTCACATTTGGCACttatttttttattttgatttttaaaaaaCACTTTAGAAAGCAAAACAATTGCTCCTCGCAGTCCCAAGTGCCCAGCCAC
Downstream sequence
AGAGGGGTTGCCCATGAGCCCCAGGCAGTAGATTGGTACCCTCAGAGCGTAGtttgtttatttatttgtttatttgagatggagtcttgctctgttgccc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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