VISDB - VIS Detail

Basic Information

VIS ID

TVIS44004212

Fusion event

HTLV-1-PLCXD1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chrX

Cytoband

p22.33

Reference genome

GRCh37/hg19

Start

211314/294647 (Hg38)

End

211314/294647 (Hg38)

Orient

Location type

Intronic

Target gene

PLCXD1

miRNAs that regulate target gene

hsa-mir-98-5p ; hsa-mir-296-3p ; hsa-let-7e-5p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-3941 ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-4643 ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-1277-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-568 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-6807-5p ; hsa-mir-6499-3p ; hsa-mir-216b-3p ; hsa-mir-6771-5p ; hsa-mir-4268 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6787-3p ; hsa-mir-6746-5p ; hsa-mir-4768-3p ; hsa-mir-6736-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-216a-5p ; hsa-mir-34b-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-1247-3p ; hsa-mir-1827

Nearest miRNA

hsa-let-7f-2/Downstream/999271;

Nearest TSS

ENST00000429181/Upstream/10913; ENST00000391707/Downstream/17816;

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/1364, chrX-CpG: 34/Downstream/4400

Upstream sequence

tgaatccaggaggcggaggttgctgtgatccatggtcgcgccactgcactccagcctgggcgacaggagcaagactccatctcaaaacaaaacaaaaaag

Downstream sequence

agaaaaattagccaggcatggtgatgcgcgcctataatcccagctactcaggaggctgaggcaggggaatcacttgaaccaggaaggcggaggttgcagt

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.