Basic Information
VIS ID
TVIS44004230
Fusion event
HTLV-1-FAM126A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
22966270/22926651 (Hg38)
End
22966270/22926651 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM126A
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-301a-3p ; hsa-let-7b-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-8085 ; hsa-mir-3115 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-6871-5p ; hsa-mir-154-5p ; hsa-mir-548aa ; hsa-mir-548ac ; hsa-mir-548ap-3p ; hsa-mir-548bb-3p ; hsa-mir-548d-3p ; hsa-mir-548h-3p ; hsa-mir-548t-3p ; hsa-mir-548z ; hsa-mir-6715a-3p
Nearest miRNA
hsa-mir-1183/Upstream/1455505; hsa-mir-10399/Downstream/3023268;
Nearest TSS
ENST00000635602/Upstream/103799; ENST00000491352/Downstream/14539;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/71693, chr7-CpG: 87/Downstream/86701
Nearby gene
FAM126A(-14608) ;
Upstream sequence
actttaaaccaacaaagatcaaaagaaacaaagaaggccattacataatggtaaagggatcaattcaacaagaaaagctaactatcctaaatatatatgc
Downstream sequence
acccaatacaggagcacccagattcataaagcaagtcccgagtgacctacaaagagacttagactcccacacaataataatgggagactttaacacccca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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