Basic Information
VIS ID
TVIS44004234
Fusion event
HTLV-1-LINC01680 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
191196826/191227696 (Hg38)
End
191196826/191227696 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
LINC01680
Nearest miRNA
hsa-mir-101-1/Upstream/10789306; hsa-mir-1182/Downstream/1488632;
Nearest TSS
ENST00000473358/Upstream/76186; ENST00000430776/Downstream/771;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4546747, chr1-CpG: 56/Downstream/1580806
Nearby gene
LINC01720(+426038) ;
Upstream sequence
TGTTTGTAGGTTATGCAATTTAGGTAGCAAGATCATCACAAATAATTTGGATAATTCCAATATTATTTAGTGAATCTATGTCTTTATATGACTATTAGGG
Downstream sequence
GAAAAATGTGTCTTTATTGTGGTCATGCTAATATTTCTTGCTATTACTCTATATAACACTGAGGTATAGAAATATGACTATAGAATATATAAAAACAGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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