Basic Information
VIS ID
TVIS44004249
Fusion event
HTLV-1-THSD7B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
138129410/137371840 (Hg38)
End
138129410/137371840 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
THSD7B
Nearest miRNA
hsa-mir-128-1/Upstream/1706362; hsa-mir-10b/Downstream/3214786;
Nearest TSS
ENST00000437798/Upstream/215880; ENST00000480352/Downstream/270403;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/605714, chr2-CpG: 71/Downstream/1129623
Upstream sequence
tcttacattctattgaattgtttttttaatttttattttgctttgatttctgaaagatctttacttgctaaatattcttttctcatagtaagcactactg
Downstream sequence
gtttcatggtagaaatctttctgtttttcttcagtttaatagttttagtgatagtcttttcattcgcaaagttttcttccccttatcatgttttaatttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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