Basic Information
VIS ID
TVIS44004253
Fusion event
HTLV-1-ACO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
41873365/41477361 (Hg38)
End
41873365/41477361 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
ACO2
Nearest miRNA
hsa-mir-1281/Upstream/224311; hsa-let-7a-3/Downstream/423583;
Nearest TSS
ENST00000624155/Upstream/8201; ENST00000482208/Downstream/30477;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/7922, chr22-CpG: 62/Downstream/66552
Upstream sequence
tcctgcctcagcctcctgcgtagctgggactacaggcacccgccaccacgcccagctaattttttgtatttttttttttagtagagatggggtttcacgg
Downstream sequence
tgttagccaggatggtctcaatctcctgaccttgtgatccacctgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgcacccgaccTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate